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Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling.
EGF (epidermal growth factor) binding to its receptor (EGFR) induces dimerization and autophosphorylation of the receptor at multiple tyrosine residues, which serve as docking sites for recruitment of proteins with SH2 (Src homology 2) domains that activate multiple downstream signalling pathways. T...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223792/ https://ncbi.nlm.nih.gov/pubmed/14498832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030668 |
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