Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.

Beta-arrestins are cytosolic proteins that bind to activated and phosphorylated G-protein-coupled receptors [7MSRs (seven-membrane-spanning receptors)] and uncouple them from G-protein-mediated second messenger signalling pathways. The binding of beta-arrestins to 7MSRs also leads to new signals via...

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Detalles Bibliográficos
Main Authors: Shenoy, Sudha K, Lefkowitz, Robert J
Formato: Artigo
Idioma:Inglês
Publicado: 2003
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223736/
https://ncbi.nlm.nih.gov/pubmed/12959637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031076
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