Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization.

Activation of G(i)/G(o)-coupled opioid receptors increases [Ca2+]i (intracellular free-Ca2+ concentration), but only if there is concomitant G(q)-coupled receptor activation. This G(i)/G(o)-coupled receptor-mediated [Ca2+]i increase does not appear to result from further production of Ins P3 [Ins(1,...

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Detalhes bibliográficos
Main Authors: Samways, Damien S K, Li, Wen-hong, Conway, Stuart J, Holmes, Andrew B, Bootman, Martin D, Henderson, Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223709/
https://ncbi.nlm.nih.gov/pubmed/12880387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030508
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