Induction of transcripts derived from promoter III of the acetyl-CoA carboxylase-alpha gene in mammary gland is associated with recruitment of SREBP-1 to a region of the proximal promoter defined by a DNase I hypersensitive site.

ACC-alpha (acetyl-CoA carboxylase-alpha), a key regulator of fatty-acid metabolism, is encoded by mRNAs transcribed from three promoters, PI, PII and PIII, in the ovine genome. Enhanced expression of transcripts encoded by PIII in mammary gland during lactation is associated with alterations in chro...

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Hlavní autoři: Barber, Michael C, Vallance, Amanda J, Kennedy, Helen T, Travers, Maureen T
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223696/
https://ncbi.nlm.nih.gov/pubmed/12871210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030480
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