Induction of transcripts derived from promoter III of the acetyl-CoA carboxylase-alpha gene in mammary gland is associated with recruitment of SREBP-1 to a region of the proximal promoter defined by a DNase I hypersensitive site.

ACC-alpha (acetyl-CoA carboxylase-alpha), a key regulator of fatty-acid metabolism, is encoded by mRNAs transcribed from three promoters, PI, PII and PIII, in the ovine genome. Enhanced expression of transcripts encoded by PIII in mammary gland during lactation is associated with alterations in chro...

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Autores principales: Barber, Michael C, Vallance, Amanda J, Kennedy, Helen T, Travers, Maureen T
Formato: Artigo
Lenguaje:Inglês
Publicado: 2003
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223696/
https://ncbi.nlm.nih.gov/pubmed/12871210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030480
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