Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid

Accumulation of oxidative damage to mitochondria, protein, and nucleic acid in the brain may lead to neuronal and cognitive dysfunction. The effects on cognitive function, brain mitochondrial structure, and biomarkers of oxidative damage were studied after feeding old rats two mitochondrial metaboli...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Jiankang, Head, Elizabeth, Gharib, Afshin M., Yuan, Wenjun, Ingersoll, Russell T., Hagen, Tory M., Cotman, Carl W., Ames, Bruce N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC122369/
https://ncbi.nlm.nih.gov/pubmed/11854529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261709299
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