Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine.

Racemic difluoromethylornithine (D/L-DFMO) is an inhibitor of ODC (ornithine decarboxylase), the first enzyme in eukaryotic polyamine biosynthesis. D/L-DFMO is an effective anti-parasitic agent and inhibitor of mammalian cell growth and development. Purified human ODC-catalysed ornithine decarboxyla...

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Autori principali: Qu, Ning, Ignatenko, Natalia A, Yamauchi, Phillip, Stringer, David E, Levenson, Corey, Shannon, Patrick, Perrin, Scott, Gerner, Eugene W
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2003
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223689/
https://ncbi.nlm.nih.gov/pubmed/12859253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030382
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