Identification of SNARE complex modulators that inhibit exocytosis from an alpha-helix-constrained combinatorial library.

Synthetic peptides patterned after the proteins involved in vesicle fusion [the so-called SNARE (soluble N -ethylmaleimide-sensitive fusion protein attachment protein receptor) proteins] are potent inhibitors of SNARE complex assembly and neuronal exocytosis. It is noteworthy that the identification...

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Main Authors: Blanes-Mira, Clara, Pastor, Maria T, Valera, Elvira, Fernández-Ballester, Gregorio, Merino, Jaime M, Gutierrez, Luis M, Perez-Payá, Enrique, Ferrer-Montiel, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223669/
https://ncbi.nlm.nih.gov/pubmed/12852787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030509
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