Adeno-associated virus effectively mediates conditional gene modification in the brain

The Cre/loxP system is increasingly showing promise for investigating genes involved in neural function. Here, we demonstrate that in vivo modification of genes in the mouse brain can be accomplished in a spatial- and temporal-specific manner by targeted delivery of an adeno-associated virus (AAV) e...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kaspar, Brian K., Vissel, Bryce, Bengoechea, Tasha, Crone, Steven, Randolph-Moore, Lynne, Muller, Rolf, Brandon, Eugene P., Schaffer, David, Verma, Inder M., Lee, Kuo-Fen, Heinemann, Stephen F., Gage, Fred H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11842206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042678699
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