Overexpression of UDP-glucose dehydrogenase in Escherichia coli results in decreased biosynthesis of K5 polysaccharide.

The Escherichia coli K5 capsular polysaccharide (glycosaminoglycan) chains are composed of the repeated disaccharide structure: -GlcAbeta1,4-GlcNAcalpha1,4-(where GlcA is glucuronic acid and GlcNAc is N-acetyl-D-glucosamine). The GlcA, present in most glycosaminoglycans, is donated from UDP-GlcA, wh...

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Detalhes bibliográficos
Main Authors: Roman, Elisabet, Roberts, Ian, Lidholt, Kerstin, Kusche-Gullberg, Marion
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223629/
https://ncbi.nlm.nih.gov/pubmed/12775214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030365
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