Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine.

Reactive nitrogen species, such as peroxynitrite, can nitrate tyrosine in proteins to form nitrotyrosine. Nitrotyrosine is metabolized to 3-nitro-4-hydroxyphenylacetic acid (NHPA), which is excreted in the urine. This has led to the notion that measurement of urinary NHPA may provide a time-integrat...

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Autori principali: Mani, Ali R, Pannala, Ananth S, Orie, Nelson N, Ollosson, Richard, Harry, David, Rice-Evans, Catherine A, Moore, Kevin P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2003
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223612/
https://ncbi.nlm.nih.gov/pubmed/12797864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030670
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