Monitoring disappearance of monomers and generation of resistance to proteolysis during the formation of the activation domain of human procarboxypeptidase A2 (ADA2h) amyloid fibrils by matrix-assisted laser-desorption ionization-time-of-flight-MS.

The term 'amyloidosis' is used to represent a group of protein misfolding diseases characterized by the polymerization of normally innocuous and soluble proteins or peptides into insoluble proteinaceous deposits. One of the several questions that remain unclear regarding the process of amy...

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Detalhes bibliográficos
Main Authors: Villanueva, Josep, Villegas, Virtudes, Querol, Enrique, Avilés, Francesc X, Serrano, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223600/
https://ncbi.nlm.nih.gov/pubmed/12765547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030368
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