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The soluble ectodomain of RetC634Y inhibits both the wild-type and the constitutively active Ret.
Substitution of Cys-634 in the extracellular domain of the Ret tyrosine kinase receptor causes its dimerization and activation of its transforming potential. To gain further insight into the molecular basis leading to Ret activation we purified a mutant protein consisting of the entire ectodomain of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223439/ https://ncbi.nlm.nih.gov/pubmed/12630912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021530 |
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