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Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases.
Caspases are critical for the initiation and execution of apoptosis. Nitric oxide (NO) or derived species can prevent programmed cell death in several cell types, reportedly through S-nitrosation and inactivation of active caspases. Although we find that S-nitrosation of caspases can occur in vitro,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223357/ https://ncbi.nlm.nih.gov/pubmed/12605597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021720 |
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