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Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.
In T cells, the lipid raft-associated Lck is strongly tyrosine phosphorylated and has reduced enzymic activity in contrast with the detergent-soluble pool, which has substantial activity. Lck tagged at the C-terminus (Lck/V5-His) was efficiently captured by epitope-specific reagents from the deterge...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2003
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223349/ https://ncbi.nlm.nih.gov/pubmed/12570875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021578 |
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