Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme.

Tumour necrosis factor-alpha (TNF-alpha) converting enzyme (TACE) is a membrane-anchored, multiple-domain zinc metalloproteinase responsible for the release of the potent pro-inflammatory cytokine, TNF-alpha. The extracellular part of the active enzyme is composed of a catalytic domain and several c...

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Detalhes bibliográficos
Main Authors: Lee, Meng-Huee, Dodds, Philippa, Verma, Vandana, Maskos, Klaus, Knäuper, Vera, Murphy, Gillian
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223312/
https://ncbi.nlm.nih.gov/pubmed/12556225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021538
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