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The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation.

The reciprocal pro-enzyme activation system of plasmin, urokinase-type plasminogen activator (uPA) and their respective zymogens is a potent mechanism in the generation of extracellular proteolytic activity. Plasminogen activator inhibitor type 1 (PAI-1) acts as a negative regulator. This system is...

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Detalhes bibliográficos
Main Authors: Behrendt, Niels, List, Karin, Andreasen, Peter A, Danø, Keld
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223308/
https://ncbi.nlm.nih.gov/pubmed/12534347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021508
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