Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α

Phosphatidylinositol 3-kinase is a key step in the metabolic actions of insulin. Two amino acid substitutions have been identified in the gene for the regulatory subunit of human p85α, Met-326Ile, and Asn-330Asp, and the former has been associated with alterations in glucose/insulin homeostasis. Whe...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Almind, Katrine, Delahaye, Laurent, Hansen, Torben, Van Obberghen, Emmanuel, Pedersen, Oluf, Kahn, C. Ronald
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122329/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11842213/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042688799
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