A newly established in vitro culture using transgenic Drosophila reveals functional coupling between the phospholipase A2-generated fatty acid cascade and lipopolysaccharide-dependent activation of the immune deficiency (imd) pathway in insect immunity.

Innate immunity is the first line of defence against infectious micro-organisms, and the basic mechanisms of pathogen recognition and response activation are evolutionarily conserved. In mammals, the innate immune response in combination with antigen-specific recognition is required for the activati...

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Bibliographische Detailangaben
Hauptverfasser: Yajima, Masashi, Takada, Masatoshi, Takahashi, Nahoko, Kikuchi, Haruhisa, Natori, Shunji, Oshima, Yoshiteru, Kurata, Shoichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223264/
https://ncbi.nlm.nih.gov/pubmed/12513692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021603
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