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Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies

Loss of Pax 6 function leads to an eyeless phenotype in both mammals and insects, and ectopic expression of both the Drosophila and the mouse gene leads to the induction of ectopic eyes in Drosophila, which suggested to us that Pax 6 might be a universal master control gene for eye morphogenesis. He...

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Autori principali: Onuma, Yasuko, Takahashi, Shuji, Asashima, Makoto, Kurata, Shoichiro, Gehring, Walter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC122312/
https://ncbi.nlm.nih.gov/pubmed/11842182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022626999
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