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Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).

Inhibition of de novo synthesis of phosphatidylcholine (PC) by some anti-cancer drugs such as hexadecylphosphocholine leads to apoptosis in various cell lines. Likewise, in MT58, a mutant Chinese hamster ovary (CHO) cell line containing a thermo-sensitive mutation in CTP:phosphocholine cytidylyltran...

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Bibliografiske detaljer
Main Authors: van der Sanden, Michiel H M, Houweling, Martin, van Golde, Lambert M G, Vaandrager, Arie B
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223098/
https://ncbi.nlm.nih.gov/pubmed/12370080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020285
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