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Mutation of the important Tyr-33 residue of chicken avidin: functional and structural consequences.

The strong interaction between avidin and biotin is so tight (dissociation constant 10(-15) M) that conditions usually sufficient for protein denaturing fail to dislodge biotin from the avidin-biotin complex. This kind of irreversible binding hinders the use of avidin in applications such as affinit...

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Autores principales: Marttila, Ari T, Hytönen, Vesa P, Laitinen, Olli H, Bayer, Edward A, Wilchek, Meir, Kulomaa, Markku S
Formato: Artigo
Lenguaje:Inglês
Publicado: 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223082/
https://ncbi.nlm.nih.gov/pubmed/12358604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020886
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