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Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway

Arsenite is a known human carcinogen that induces tumorigenesis through either a genotoxic or an epigenetic mechanism. In this study, the effect of arsenite on cell cycle regulation and the mechanisms that contribute to this effect were investigated. Treatment of the cells with arsenite suppressed c...

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Detalhes bibliográficos
Main Authors: Chen, Fei, Zhang, Zhuo, Bower, Jacquelyn, Lu, Yongju, Leonard, Stephen S., Ding, Min, Castranova, Vince, Piwnica-Worms, Helen, Shi, Xianglin
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122307/
https://ncbi.nlm.nih.gov/pubmed/11842186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032428899
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