Inhibition of autophagic proteolysis by inhibitors of phosphoinositide 3-kinase can interfere with the regulation of glycogen synthesis in isolated hepatocytes.

Amino acid-induced cell swelling stimulates conversion of glucose into glycogen in isolated hepatocytes. Activation of glycogen synthase (GS) phosphatase, caused by the fall in intracellular chloride accompanying regulatory volume decrease, and activation of phosphoinositide 3-kinase (PI 3-kinase),...

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Autors principals: Dubbelhuis, Peter F, Van Sluijters, Daphne A, Blommaart, Edward F C, Gustafson, Lori A, Van Woerkom, George M, Herling, Andreas W, Burger, Hans-Joerg, Meijer, Alfred J
Format: Artigo
Idioma:Inglês
Publicat: 2002
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223050/
https://ncbi.nlm.nih.gov/pubmed/12371905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021340
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