Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling.

The tyrosine phosphatase SHP-1 (Src homology phosphatase-1) has been widely implicated as a negative regulator of signalling in immune cells. We have investigated in detail the role of SHP-1 in interleukin-3 (IL-3) signal transduction by inducibly expressing wild-type (WT), C453S (substrate-trapping...

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Detalhes bibliográficos
Main Authors: Paling, Nicholas R D, Welham, Melanie J
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223032/
https://ncbi.nlm.nih.gov/pubmed/12220225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021054
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