Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction. NMR and other analyses of a hydroxylated HIF fragment pr...

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Autori principali: McNeill, Luke A, Hewitson, Kirsty S, Claridge, Timothy D, Seibel, Jürgen F, Horsfall, Louise E, Schofield, Christopher J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2002
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222951/
https://ncbi.nlm.nih.gov/pubmed/12215170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021162
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