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Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice

C75 is a potent inhibitor of fatty acid synthase that acts centrally to reduce food intake and body weight in mice; a single dose causes a rapid (>90%) decrease of food intake. These effects are associated with inhibition of fasting-induced up-regulation and down-regulation, respectively, of the...

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Autors principals: Kumar, Monica V., Shimokawa, Teruhiko, Nagy, Tim R., Lane, M. Daniel
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC122295/
https://ncbi.nlm.nih.gov/pubmed/11854492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.042683699
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