Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.

We have recently demonstrated that the beta subunit of the heterotrimeric G-proteins is endogenously mono-ADP-ribosylated in intact cells. The modified betagamma heterodimer loses its ability to inhibit calmodulin-stimulated type 1 adenylate cyclase and, remarkably, is de-ADP-ribosylated by a cytoso...

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Detalhes bibliográficos
Main Authors: Lupi, Rosita, Dani, Nadia, Dietrich, Alexander, Marchegiani, Adriano, Turacchio, Sabrina, Berrie, Christopher P, Moss, Joel, Gierschik, Peter, Corda, Daniela, Di Girolamo, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222935/
https://ncbi.nlm.nih.gov/pubmed/12149126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020660
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