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Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore.

Opening of the mitochondrial permeability transition pore (MPTP) is sensitized to [Ca(2+)] by oxidative stress (diamide) and phenylarsine oxide (PAO). We have proposed that both agents cross-link two thiol groups on the adenine nucleotide translocase (ANT) involved in ADP and cyclophilin-D (CyP-D) b...

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Bibliografski detalji
Glavni autori: McStay, Gavin P, Clarke, Samantha J, Halestrap, Andrew P
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222909/
https://ncbi.nlm.nih.gov/pubmed/12149099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20011672
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