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Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore.

Opening of the mitochondrial permeability transition pore (MPTP) is sensitized to [Ca(2+)] by oxidative stress (diamide) and phenylarsine oxide (PAO). We have proposed that both agents cross-link two thiol groups on the adenine nucleotide translocase (ANT) involved in ADP and cyclophilin-D (CyP-D) b...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McStay, Gavin P, Clarke, Samantha J, Halestrap, Andrew P
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2002
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222909/
https://ncbi.nlm.nih.gov/pubmed/12149099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20011672
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