Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

Mitochondrial-supported bioenergetics decline and oxidative stress increases during aging. To address whether the dietary addition of acetyl-l-carnitine [ALCAR, 1.5% (wt/vol) in the drinking water] and/or (R)-α-lipoic acid [LA, 0.5% (wt/wt) in the chow] improved these endpoints, young (2–4 mo) and o...

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Hlavní autoři: Hagen, Tory M., Liu, Jiankang, Lykkesfeldt, Jens, Wehr, Carol M., Ingersoll, Russell T., Vinarsky, Vladimir, Bartholomew, James C., Ames, Bruce N.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC122286/
https://ncbi.nlm.nih.gov/pubmed/11854487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261708898
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