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Mechanism of action and NAD(+)-binding mode revealed by the crystal structure of l-histidinol dehydrogenase

The histidine biosynthetic pathway is an ancient one found in bacteria, archaebacteria, fungi, and plants that converts 5-phosphoribosyl 1-pyrophosphate to l-histidine in 10 enzymatic reactions. This pathway provided a paradigm for the operon, transcriptional regulation of gene expression, and feedb...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Barbosa, João A. R. G., Sivaraman, J., Li, Yunge, Larocque, Robert, Matte, Allan, Schrag, Joseph D., Cygler, Miroslaw
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122284/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11842181/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.022476199
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