Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity.

Tyrosine nitration is a post-translational protein modification with potentially significant biological implications. In the present study we demonstrate, for the first time, that tyrosine residues of human inducible nitric oxide synthase (NOS2) can be nitrated by peroxynitrite in vitro, leading to...

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Detalhes bibliográficos
Main Authors: Lanone, Sophie, Manivet, Philippe, Callebert, Jacques, Launay, Jean-Marie, Payen, Didier, Aubier, Michel, Boczkowski, Jorge, Mebazaa, Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222810/
https://ncbi.nlm.nih.gov/pubmed/12097137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020339
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