Optimizing bioconversion pathways through systems analysis and metabolic engineering

We demonstrate a general approach for metabolic engineering of biocatalytic systems comprising the uses of a chemostat for strain improvement and radioisotopic tracers for the quantification of pathway fluxes. Flux determination allows the identification of target pathways for modification as valida...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Stafford, Daniel E., Yanagimachi, Kurt S., Lessard, Philip A., Rijhwani, Sushil K., Sinskey, Anthony J., Stephanopoulos, Gregory
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122274/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854482/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.032681699
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