Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme.

We previously reported that full-length tissue inhibitor of metalloproteinase-3 (TIMP-3) and its N-terminal domain form (N-TIMP-3) displayed equal binding affinity for tissue necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE). Based on the computer graphic of TACE docked with a TIMP-3 model,...

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Bibliografske podrobnosti
Main Authors: Lee, Meng-Huee, Verma, Vandana, Maskos, Klaus, Nath, Deepa, Knäuper, Vera, Dodds, Philippa, Amour, Augustin, Murphy, Gillian
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222565/
https://ncbi.nlm.nih.gov/pubmed/11988096
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