Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability.

Certain vitamin E analogues, such as alpha-tocopheryl succinate (alpha-TOS), exhibit in vivo anti-tumour activity and, in vitro, induce apoptosis of cultured tumour cells. In the present study we report that these effects may be explained, at least in part, by destabilization of lysosomal membranes....

Full description

Saved in:
Bibliographic Details
Main Authors: Neuzil, Jiri, Zhao, Ming, Ostermann, Georg, Sticha, Martin, Gellert, Nina, Weber, Christian, Eaton, John W, Brunk, Ulf T
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222436/
https://ncbi.nlm.nih.gov/pubmed/11879199
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items