Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability.

Certain vitamin E analogues, such as alpha-tocopheryl succinate (alpha-TOS), exhibit in vivo anti-tumour activity and, in vitro, induce apoptosis of cultured tumour cells. In the present study we report that these effects may be explained, at least in part, by destabilization of lysosomal membranes....

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Hauptverfasser: Neuzil, Jiri, Zhao, Ming, Ostermann, Georg, Sticha, Martin, Gellert, Nina, Weber, Christian, Eaton, John W, Brunk, Ulf T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222436/
https://ncbi.nlm.nih.gov/pubmed/11879199
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