Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro.

Maurotoxin (MTX) is a 34-mer scorpion toxin cross-linked by four disulphide bridges that acts on various K(+) channels, including the voltage-gated Shaker B subtype. In the present study, we have investigated over 80 h: (1) the time-course of folding of synthetic MTX (sMTX) by CD analysis; (2) the k...

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Hauptverfasser: di Luccio, Eric, Matavel, Alessandra, Opi, Sandrine, Regaya, Imed, Sandoz, Guillaume, M'barek, Sarrah, Carlier, Edmond, Estève, Eric, Carrega, Louis, Fajloun, Ziad, Rochat, Hervé, Loret, Erwann, de Waard, Michel, Sabatier, Jean-Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222322/
https://ncbi.nlm.nih.gov/pubmed/11772414
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