Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin.

The side chain of residue Arg(238) in morphinone reductase (MR) is located close to the N-1/C-2 carbonyl region of the flavin isoalloxazine ring. During enzyme reduction negative charge develops in this region of the flavin. The positioning of a positively charged side chain in the N-1/C-2 carbonyl...

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Autors principals: Craig, D H, Barna, T, Moody, P C, Bruce, N C, Chapman, S K, Munro, A W, Scrutton, N S
Format: Artigo
Idioma:Inglês
Publicat: 2001
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222149/
https://ncbi.nlm.nih.gov/pubmed/11583577
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