Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.

Although MK886 was originally identified as an inhibitor of 5-lipoxygenase activating protein (FLAP), recent data demonstrate that this activity does not underlie its ability to induce apoptosis [Datta, Biswal and Kehrer (1999) Biochem. J. 340, 371--375]. Since FLAP is a fatty-acid binding protein,...

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Bibliographic Details
Main Authors: Kehrer, J P, Biswal, S S, La, E, Thuillier, P, Datta, K, Fischer, S M, Vanden Heuvel, J P
Format: Artigo
Language:Inglês
Published: 2001
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221919/
https://ncbi.nlm.nih.gov/pubmed/11389700
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