Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells.

A well-established protocol to increase the intracellular content of ascorbic acid was used to investigate the effects of the vitamin on DNA single-strand breakage and toxicity mediated by authentic peroxynitrite (ONOO(-)) in U937 cells. This protocol involved exposure for 60 min to 100 microM dehyd...

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Detalhes bibliográficos
Main Authors: Guidarelli, A, De Sanctis, R, Cellini, B, Fiorani, M, Dachà, M, Cantoni, O
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221863/
https://ncbi.nlm.nih.gov/pubmed/11368779
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