In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.

In a Flemish kindred, an Ala(692)-->Gly amino acid substitution in the amyloid beta-protein precursor (AbetaPP) causes a form of early-onset Alzheimer's disease (AD) which displays prominent amyloid angiopathy and unusually large senile plaque cores. The mechanistic basis of this Flemish for...

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Detalles Bibliográficos
Main Authors: Walsh, D M, Hartley, D M, Condron, M M, Selkoe, D J, Teplow, D B
Formato: Artigo
Idioma:Inglês
Publicado: 2001
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221805/
https://ncbi.nlm.nih.gov/pubmed/11311152
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