Occurrence of paradoxical or sustained control by an enzyme when overexpressed: necessary conditions and experimental evidence with regard to hepatic glucokinase.

It is widely assumed that the control coefficient of an enzyme on pathway flux decreases as the concentration of enzyme increases. However, it has been shown [Kholodenko and Brown (1996) Biochem. J. 314, 753-760] that enzymes with sigmoidal kinetics can maintain or even gain control with an increase...

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Detaylı Bibliyografya
Asıl Yazarlar: De Atauri, P, Acerenza, L, Kholodenko, B N, De La Iglesia, N, Guinovart, J J, Agius, L, Cascante, M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2001
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221796/
https://ncbi.nlm.nih.gov/pubmed/11311143
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