Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex

Wnt signaling plays a key role in cell proliferation and development. Recently, casein kinase I (CKI) and protein phosphatase 2A (PP2A) have emerged as positive and negative regulators of the Wnt pathway, respectively. However, it is not clear how these two enzymes with opposing functions regulate W...

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Autores principales: Gao, Zhong-Hua, Seeling, Joni M., Hill, Virginia, Yochum, April, Virshup, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC122164/
https://ncbi.nlm.nih.gov/pubmed/11818547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032468199
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