Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions.

Ítems similars

• Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
  per: Daugherty, A, et al.
  Publicat: (1994)
• Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.
  per: Anderson, M M, et al.
  Publicat: (1997)
• Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques.
  per: Katz, S S, et al.
  Publicat: (1976)
• 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
  per: Hazen, S. L., et al.
  Publicat: (1997)
• Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition
  per: Roth Flach, Rachel J., et al.
  Publicat: (2019)