The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis.

CrkII, a 40 kDa adaptor possessing a Src homology (SH)2 domain followed by two SH3 domains, although not endowed with catalytic activity, participates in intracellular signalling, presumably by activating the Ras pathway. CrkII was found to be phosphorylated in response to hepatocyte growth factor/s...

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Dettagli Bibliografici
Autori principali: Riordan, S M, Lidder, S, Williams, R, Skouteris, G G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2000
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221328/
https://ncbi.nlm.nih.gov/pubmed/10970810
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