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Vacuolar proton pyrophosphatase activity and pyrophosphate (PPi) in Toxoplasma gondii as possible chemotherapeutic targets.

The addition of PP(i) promoted the acidification of a subcellular compartment in cell homogenates of Toxoplasma gondii tachyzoites, implying the presence of a proton-translocating pyrophosphatase. The proton gradient was collapsed by addition of the K(+)/H(+) antiporter nigericin, and was also inhib...

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Detalhes bibliográficos
Main Authors: Rodrigues, C O, Scott, D A, Bailey, B N, De Souza, W, Benchimol, M, Moreno, B, Urbina, J A, Oldfield, E, Moreno, S N
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221200/
https://ncbi.nlm.nih.gov/pubmed/10903134
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