The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

BACKGROUND: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the SCF(SKP2) ubiquitin...

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Bibliographic Details
Main Authors: Lu, Lifang, Schulz, Holger, Wolf, Dieter A
Format: Artigo
Language:Inglês
Published: BioMed Central 2002
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC122093/
https://ncbi.nlm.nih.gov/pubmed/12188931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-3-22
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