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The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells
BACKGROUND: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the SCF(SKP2) ubiquitin...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122093/ https://ncbi.nlm.nih.gov/pubmed/12188931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-3-22 |
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