GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis.

Different cytotoxic drugs induce cell death by activating the apoptotic programme; a family of cysteinyl aspartate proteases named caspases has been shown to be involved in the initiation as well as the execution of this kind of cell death. In the present study, cleavage of D4-GDI (Rho-GDI 2), an ab...

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Main Authors: Essmann, F, Wieder, T, Otto, A, Müller, E C, Dörken, B, Daniel, P T
格式: Artigo
語言:Inglês
出版: 2000
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220912/
https://ncbi.nlm.nih.gov/pubmed/10698706
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