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Histone synthesis in Leishmania infantum is tightly linked to DNA replication by a translational control.

We have analysed the regulation of histone synthesis in Leishmania infantum following inhibition of DNA replication. Run-on experiments indicated that transcription rates of the genes coding for the four core histones (H2A, H2B, H3 and H4) were not affected by the inhibition with hydroxyurea of DNA...

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Autori principali: Soto, M, Quijada, L, Alonso, C, Requena, J M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220828/
https://ncbi.nlm.nih.gov/pubmed/10657245
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