Oligomerization reduces heparin affinity but enhances receptor binding of fibroblast growth factor 2.

The biological response of cells to fibroblast growth factors (FGFs) depends on heparan sulphate glycosaminoglycans sharing particular structural motifs. Heparin induced FGF dimerization has been suggested to mediate receptor dimerization and activation. Here we demonstrate that heparin-derived olig...

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Hlavní autoři: Safran, M, Eisenstein, M, Aviezer, D, Yayon, A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220736/
https://ncbi.nlm.nih.gov/pubmed/10600645
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